Faculty in this research area share a strong interest and broad expertise in molecular and clinical aspects of the prevention, development, diagnosis and treatment of cancer.  Some are clinicians treating pets at the Flint Animal Cancer Center and collaborating with the human medical field to translate research discoveries into new treatments for both people and animals. Others leverage molecular and genetic approaches to define the molecular mechanisms underlying genetic instability associated with cancer.  Nutrition and other environmental influences, particularly radiation, are also a major focus for cancer biology researchers in CMB.

Faculty

J Lucas Argueso

J Lucas Argueso
Associate Professor (Environmental & Radiological Health Sciences)
Molecular mechanisms of Copy Number Variation (CNV) and other chromosomal rearrangements. Genomics of industrial yeast strains

Susan Bailey

Susan M. Bailey
Professor (Environmental & Radiology Health Sciences)
Role of dysfunctional telomeres in tumorigenesis.  NASA Twins Study.

Mark BrownMark Brown
Associate Professor (Clinical Sciences)
Molecular oncology and small molecule drug development.

Jake (Jennifer) DeLuca Jennifer G. DeLuca
Professor (Biochemistry & Molecular Biology)
Mechanisms of Mitotic Chromosome Segregation.

Steven DowSteven W. Dow
Professor (Microbiology, Immunology & Pathology and Clinical Sciences)
Developing new immunotherapies to treat cancer, including cancer vaccines, repurposed immunotherapy drugs, and checkpoint targeted immunotherapies. Rodent models, dog cancer clinical trials, and collaborative studies in human clinical trials.

Dawn Duval Dawn L. Duval
Associate Professor (Clinical Sciences)
Molecular mechanisms of carcinogenesis and metastasis in osteosarcoma and breast cancer .

Nicole Ehrhart Nicole Ehrhart
Professor (Clinical Sciences)
Limb preservation; musculoskeletal sarcoma; orthopaedic oncology; bone regeneration, and tissue engineering.

David Frisbie David D. Frisbie
Professor (Clinical Sciences)
In vitro and in vivo approaches to diagnostic and therapeutic musculoskeletal disease.

Daniel Gustafson Daniel L. Gustafson
Professor (Clinical Sciences)
Cancer pharmacology, pharmacokinetics and toxicology.

Jeff Hansen

Jeff Hansen
Professor (Biochemistry & Molecular Biology)
Higher order chromatin structure and chromatin architectural proteins.

Taka Kato

Takamitsu Kato
Associate Professor (Environmental & Radiological Health Sciences)
DNA damage and repair after environmental stress including ionizing radiation, ultraviolet light, heat, mutagenic and carcinogenic compounds.

Steven Markus Steven Markus
Assistant Professor (Biochemistry & Molecular Biology)
Mechanisms regulating motor based transport in cells during mitosis

Jean Peccoud Jean Peccoud
Professor (Chemical & Biological Engineering)
Predictive models of the phenotype encoded in natural and synthetic DNA sequences.

Dan Regan

Dan Regan
Assistant Professor (Microbiology, Immunology & Pathology)
Interplay between the immune system and tumor stroma.  Resistance to therapy.

Elizabeth RyanElizabeth Ryan
Associate Professor (Environmental & Radiological Health Sciences)
Interactions of food components with gut microbiota and the immune system.
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Douglas Thamm with dogDouglas H. Thamm
Professor (Clinical Sciences)
Signal transduction and its inhibition in comparative cancer models.

Henry J. ThompsonHenry Thompson
Professor (Horticulture & Landscape Architecture)
Biochemical and molecular approaches to cancer prevention; preclinical models and clinical investigations.

Tiffany Weir Tiffany Weir
Associate Professor (Food Science & Human Nutrition)
Role of microbes in ecosystems ranging from soils to processed food products to the human gut.

Claudia Wiese Claudia Wiese
Assistant Professor (Environmental & Radiological Health Sciences)
Molecular mechanisms of DNA repair, genome integrity, and  cancer avoidance.

TingTing Yao TingTing Yao
Associate Professor (Biochemistry & Molecular Biology)
Regulation of gene expression and chromatin dynamics by the ubiquitin – proteasome pathway.

Affiliate Faculty

Affiliate Faculty serve as committee members or participate in the program in other ways but are not currently taking CMB students in their labs.

Robert Cohen
Professor (Biochemistry & Molecular Biology)
Regulation of ubiquitin – dependent signaling, protein degradation, and deubiquitination.

Laurie A. Stargell
Professor &  Chair (Biochemistry & Molecular Biology)
Mechanisms of transcription initiation in yeast

Paul J. Laybourn
Professor (Biochemistry and Molecular Biology)
The mechanism of transcription regulation in a chromatin context.

Michael M. Weil
Professor (Environmental & Radiological Health Sciences)
Genetic susceptibility to radiation – induced cancers.

Charles S. Henry
Professor (Chemistry)
Bioanalytical chemistry; chemical separations and chemical nature of disease.

Susan Kraft
Professor (Environmental & Radiological Health Sciences)
Cancer imaging, Magnetic Resonance Imaging and spectroscopy, radiation therapy and neuroradiology.

Susan M. LaRue
Professor (Environmental & Radiological Health Sciences)
Experimental therapeutics; hyperthermia; tumor physiology; tumor cytogenetics.

Jac A. Nickoloff
Professor (Environmental & Radiological Health Sciences)
Cellular processes that maintain eukaryotic genome stability, including homologous recombination, nonhomologous end – joining and other DNA repair processes.

Ashok Prasad
Associate Professor (Chemical and Biological Engineering and School of Biomedical Engineering)
Mathematical and computational modeling of biological processes.

James R. Bamburg
Professor (Biochemistry and Molecular Biology)
Regulation of the cytoskeleton in neuronal growth and pathfinding; signal transduction pathways regulating actin dynamics; abnormalities in actin behavior in neurodegenative diseases.

Rodney Page
Professor (Clinical Sciences)
Director of the Flint Animal Cancer Center.

Sandra L. Quackenbush
Professor, (Microbiology, Immunology & Pathology)
Viral pathogenesis, particularly viral – induced oncogenesis.

Amy MacNeill
Associate Professor, (Microbiology, Immunology & Pathology)
Isolation and characterization of canine and feline tumor cells and the study of poxviruses as anticancer agent

Coursework

ERHS / VS 510 Cancer Biology
ERHS 611 Cancer Genetics
ERHS 733 Environmental Carcinogenesis
VS 780 Cancer Biology Clinical Practicum

ERHS 530 Radiological Physics and Dosimetry I
ERHS 630 Radiological Physics and Dosimetry II
ERHS 550 Principles of Radiation Biology
ERHS 701 Advanced Diagnostic Imaging Modalities
EHRS 714 Radiation Therapy Physics

See also the Cancer Biology Specialization

Resources & Facilities

CMB Students

Ilham AlshiraihiIlham Alshiraihi (Brown Lab)

Taghreed Al TurkiTaghreed Al Turki (Bailey Lab)

Sam BrillSam Brill (Thamm Lab)
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Katie CroniseKatie Cronise (Duval Lab)

Matthew DilsaverMatt Dilsaver (Markus Lab)
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CSU Ram logoSuad Elmegerhi (Kato Lab)
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Amy Hodges Amy Hodges (DeLuca Lab)

Jared LuxtonJared Luxton (Bailey Lab)
Summer 2019 Cancer Biology & Comparative Oncology Fellow
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Alissa MathiasAlissa Mathias (Regan Lab)
Summer 2019 Cancer Biology & Comparative Oncology Fellow
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Sean Merriman Sean Merriman (Argueso Lab)
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Elena PiresElena Pires (Wiese Lab)

Lisa SchleinLisa Schlein DVM (Thamm Lab)
CCTSI – TL1 – TOTTS Fellow 2018 – 19
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Platon SelemenakisPlaton Selemenakis (Wiese Lab)
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Alumni

Nouf Alyami (PhD 2019, Duval Lab)

Nora Jean Nealon (PhD 2019 Ryan Lab) – Completing DVM at Colorado State

Genevieve Hartley (PhD 2018 Dow Lab) – Post-doctoral Fellow at MD Anderson Cancer Center

Lyndah Chow (PhD 2018 Dow Lab) – Post-doctoral Fellow at Colorado State University

Hailey Sedam (PhD 2018, Argueso Lab) – Post – doctoral Fellow, University of New Mexico

Nadia Sampaio (PhD 2018, Argueso Lab) – Post-doctoral Fellow Boston University

Tymofiy Lutsiv (MS 2018, Thompson Lab) – PhD program at Loyola University

Miles McKenna (PhD 2017, Bailey Lab) – Bioscience Specialist at Nikon Instruments

Christopher Nelson (PhD 2017, Bailey Lab) – Post – doctoral Fellow Children’s Medical Institute, Sydney, Australia

Melissa Edwards (PhD 2016, Brown Lab) – Associate Director, Office of Undergraduate Research and Artistry, CSU

Publications