Genome Repair

CMB faculty study genomes from many perspectives including epigenetics, telomeres, replication, transcriptional regulation, damage, repair and evolution.

Faculty

J Lucas Argueso

J Lucas Argueso
Associate Professor (Environmental & Radiological Health Sciences)
Molecular mechanisms of Copy Number Variation (CNV) and other chromosomal rearrangements. Genomics of industrial yeast strains

Susan Bailey Headshot

Susan M. Bailey
Professor (Environmental & Radiology Health Sciences)
Role of dysfunctional telomeres in tumorigenesis.  NASA Twins Study.

Jennifer G. DeLucaJennifer DeLuca Headshot
Professor (Biochemistry & Molecular Biology)
Mechanisms of Mitotic Chromosome Segregation.

Kim HokeKim Hoke
Associate Professor (Biology)
Mechanisms for convergent evolution of behavioral and morphological traits

Tom LaRocca

Tom LaRocca
Assistant Professor (Heath & Exercise Science)
Biological mechanisms of healthspan, including proteome, genome and RNA homeostasis, and their effects on organismal function and brain health.

Tom SantangeloTom Santangelo
Associate Professor (Biochemistry & Molecular Biology)
Archaeal transcription and chromatin

Dan SloanDan Sloan
Associate Professor (Biology)
Evolutionary forces that shape cyto – nuclear interactions at the genome level.
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mark stengleinMark Stenglein
Assistant Professor (Microbiology, Immunology & Pathology)
Virology. Computational Biology. Bioinformatics. Genomics. Virus discovery. Virus evolution.

Claudia WieseClaudia Wiese Headshot
Assistant Professor (Environmental & Radiological Health Sciences)
Molecular mechanisms of DNA repair, genome integrity, and cancer avoidance.

Affiliate Faculty

Robert Cohen
Professor (Biochemistry & Molecular Biology)
Histone ubiquitylation and chromatin remodeling

Jeff Hansen
Professor (Biochemistry & Molecular Biology)
Higher order chromatin structure and chromatin architectural proteins.

Shing Ho
Professor (Biochemistry & Molecular Biology)
Structures and structural gymnastics associated with the functions of nucleic acids. Halogen bonds for bioengineering and rational drug design.

Laurie Stargell
Professor (Biochemistry & Molecular Biology)
RNA polymerase II transcription and chromatin context in S. cerevisiae.

Mike Weil
Professor (Environmental & Radiological Health Sciences)
Gene mutation by radiation

Coursework

  • BSPM 575  Molecular and Genomic Evolution
  • BZ 460  Genome Evolution
  • BZ 575  Molecular and Genomic Evolution

Facilities & Resources

The Histone Source (Protein Expression & Purification Facility)

Next Generation Sequencing Core Facility

CMB Students

Joseph Stewart (DeLuca Lab)
(PhD, 2019 Cohort)
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Amy Hodges (DeLuca Lab)Amy Hodges

Jared LuxtonJared Luxton (Bailey Lab)
Summer 2019 Cancer Biology & Comparative Oncology Fellow
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Sere Williams (Santangelo Lab)
(PhD, 2019 Cohort)
qCMB T32 Fellow 2020 – 21
AAAS Mass Media Fellow 2020
GAUSSI Fellow 2018-2019
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AAAS MMF

Sean Merriman HeadshotSean Merriman (Argueso Lab)
qCMB T32 Fellow 2019 – 20
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Kristin Scott HeadshotKristin Scott (Santangelo Lab)
GAANN Teaching Fellow 2018 – 19
qCMB T32 Fellow 2019 – 20
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Platonas SelemenakisPlaton Selemenakis (Wiese Lab)
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Alissa WilliamsAlissa Williams (Sloan Lab)
GAANN Teaching Fellow 2016
NSF – GRFP Fellow 2017 – 18
qCMB T32 Pre – doctoral Fellow 2019
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Alumni

Taghreed Altruki HeadshotTaghreed Al Turki (Bailey Lab)
Postdoctoral Fellow at UNC Lineberger in the Griffith lab.

Elena PiresElena Pires (Wiese Lab)
Completing DVM at Colorado State University

Hailey Sedam (PhD 2018, Argueso Lab) -Clinical Genomics Scientist at Myriad Women’s Health

Nadia Sampaio (PhD 2018, Argueso Lab) – Research Scientist at Brazilian Biorenewables National Laboratory

Kate Rockenbach (MS 2017, Sloan Lab) – Research Assistant at Anheuser – Busch InBev

Miles McKenna (PhD 2017, Bailey Lab) – Bioscience Specialist at Nikon Instruments

Christopher Nelson (PhD 2017, Bailey Lab) – Post – doctoral Fellow Children’s Medical Institute, Sydney, Australia

Publications

Chromosome Translocations, Inversions and Telomere Length for Retrospective Biodosimetry on Exposed U.S. Atomic Veterans. McKenna MJ, Robinson E, Taylor L, Tompkins C, Cornforth MN, Simon SL, Bailey SM. Radiat Res. 2019 191(4):311-322.

Both R-loop removal and ribonucleotide excision repair activities of RNase H2 contribute substantially to chromosome stability. Cornelio DA, Sedam HN, Ferrarezi JA, Sampaio NM, Argueso JL. DNA Repair (Amst). 2017 52:110-114

A Case Study of Genomic Instability in an Industrial Strain of Saccharomyces cerevisiae. Rodrigues-Prause A, Sampaio NMV, Gurol TM, Aguirre GM, Sedam HNC, Chapman MJ, Malc EP, Ajith VP, Chakraborty P, Tizei PA, Pereira GAG, Mieczkowski PA, Nishant KT, Argueso JL. G3 (Bethesda). 2018 8(11):3703-3713.

Selfish Mitonuclear Conflict. Havird JC, Forsythe ES, Williams AM, Werren JH, Dowling DK, Sloan DB. Curr Biol. 2019 29(11):R496-R511.

Extreme variation in rates of evolution in the plastid Clp protease complex. Williams AM, Friso G, van Wijk KJ, Sloan DB. Plant J. 2019 98:243-259.

Cytonuclear integration and co-evolution. Sloan DB, Warren JM, Williams AM, Wu Z, Abdel-Ghany SE, Chicco AJ, Havird JC. Nat Rev Genet. 2018 19(10):635-648.